General Information

  • ID:  hor005312
  • Uniprot ID:  P10997
  • Protein name:  Islet amyloid polypeptide
  • Gene name:  IAPP
  • Organism:  Homo sapiens (Human)
  • Family:  Calcitonin family
  • Source:  Human
  • Expression:  NA
  • Disease:  Diseases associated with IAPP include Insulinoma and Amyloidosis.
  • Comments:  NA
  • Taxonomy:  Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0001540 amyloid-beta binding; GO:0005102 signaling receptor binding; GO:0005179 hormone activity; GO:0005515 protein binding; GO:0008289 lipid binding; GO:0042802 identical protein binding; GO:0048018 receptor ligand activity
  • GO BP:  GO:0006915 apoptotic process; GO:0007165 signal transduction; GO:0007267 cell-cell signaling; GO:0010739 positive regulation of protein kinase A signaling; GO:0010823 negative regulation of mitochondrion organization; GO:0019233 sensory perception of pain; GO:0030316 osteoclast differentiation; GO:0031333 negative regulation of protein-containing complex assembly; GO:0042755 eating behavior; GO:0043065 positive regulation of apoptotic process; GO:0043410 positive regulation of MAPK cascade; GO:0043950 positive regulation of cAMP-mediated signaling; GO:0045453 bone resorption; GO:0045671 negative regulation of osteoclast differentiation; GO:0045779 negative regulation of bone resorption; GO:0050850 positive regulation of calcium-mediated signaling; GO:0097647 amylin receptor signaling pathway; GO:1905907 negative regulation of amyloid fibril formation
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY
  • Length:  37
  • Propeptide:  MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLPL
  • Signal peptide:  MGILKLQVFLIVLSVALNHLKA
  • Modification:  T37 Tyrosine amide
  • Glycosylation:  NA
  • Mutagenesis:  15-15F->A,D,S: Promotes formation of fibrillar aggregates.

Activity

  • Function:  Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
  • Mechanism:  IAPP is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  2-7
  • Structure ID:  AF-P10997-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005312_AF2.pdbhor005312_ESM.pdb

Physical Information

Mass: 454862 Formula: C165H262N50O56S2
Absent amino acids: DEMPW Common amino acids: N
pI: 8.8 Basic residues: 3
Polar residues: 21 Hydrophobic residues: 12
Hydrophobicity: -9.73 Boman Index: -5510
Half-Life: 1.3 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 68.65
Instability Index: 194.32 Extinction Coefficient cystines: 1615
Absorbance 280nm: 44.86

Literature

  • PubMed ID:  3317417
  • Title:  Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.
  • PubMed ID:  2091067
  • Title:   Isolation and identification of islet amyloid polypeptide in normal human pancreas.
  • PubMed ID:  3535798
  • Title:   A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas